Serge Van Khache was born in 1946 in Angoulême. His mother was french and his father an Asian.

Stuying painting at the Ecole des Beaux-Arts in Angoulème, he was learning a lot about photography with his father in the same time. He settled in Paris as a photographer and illustrator. He worked for a lot of magazines such as Lui, Play Bpy, Vogue and in the cinema, in some films by André Cayatte, Agnès Varda as well as Roger Hanin.

In 1984, he decided to exclusively devote himself to painting. His work is in a visionnary kind of art. His technique for creating glazing looks like the flamand masters. His rigour and meticulouness take inspiration from his asian origins that characterise his painting.

In 1998, he decided to be exclusively exhibited in Galerie Mickaël Marciano, at Place des Vosges, in Paris.